Immune + Antimicrobial
LL-37
A host-defense peptide delivered sublingually to support immune regulation, antimicrobial defense, and tissue repair.
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Overview
Pharmacology
LL-37 is the only human cathelicidin peptide, produced naturally by epithelial cells and immune cells in response to infection and injury. Sublingual delivery allows direct mucosal absorption, bypassing first-pass metabolism for systemic bioavailability.
Mechanism of Action
LL-37 disrupts microbial membranes through amphipathic helical structure, directly neutralizing bacteria, fungi, and enveloped viruses. It modulates innate immune signaling via TLR4 and FPRL1 receptors, promoting anti-inflammatory cytokine balance and stimulating tissue repair through EGFR and Wnt pathway activation.
Oral
Sublingual · Apply drops under the tongue and hold for 60 seconds before swallowing.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Immune Modulation
Activates innate immune receptors to regulate inflammatory response without suppressing adaptive immunity.
Antimicrobial Defense
Directly disrupts bacterial and fungal membranes and neutralizes enveloped viruses at the mucosal level.
Wound Healing
Stimulates keratinocyte migration and angiogenesis through EGFR activation, accelerating tissue repair.
Gut Mucosal Support
Sublingual absorption supports mucosal immunity along the GI tract via systemic cathelicidin distribution.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
Simple. Medical.
Personalized.
Medical intake
Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.
Provider evaluation
A licensed medical provider reviews your intake to determine the safest, personalized treatment.
Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.
All eligibility is reviewed by a licensed medical professional
FAQs
What is LL37 Sublingual Drops?
LL37 Sublingual Drops is a prescription therapy used for immune support.
Who should use LL37 Sublingual Drops?
Patients seeking support for immune support may qualify after evaluation by a licensed provider.
Does LL37 require a prescription?
Yes. LL-37 is a compounded peptide requiring a valid prescription from a licensed provider.
What are the possible side effects?
Mild mucosal irritation or tingling under the tongue is the most common effect. Systemic reactions are rare but may include transient flushing or GI discomfort.
Who should not use LL37?
Not for patients with known hypersensitivity to cathelicidin peptides. Patients with active autoimmune conditions should consult their provider before use.
Are there any drug interactions?
No well-established drug interactions have been identified. Disclose all medications to your provider, particularly immunosuppressants, given LL-37's immunomodulatory activity.
Is LL37 safe if I have a pre-existing medical condition?
Patients with autoimmune disorders or those on immunosuppressive therapy require provider evaluation before use. Safety data in pregnancy is insufficient; avoid during pregnancy.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.