Detox + Liver protection + gut Health

Glutathione

Your body's master antioxidant delivered by injection for deep cellular detoxification and immune support.

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  • Syringes Included

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Overview

Pharmacology

Glutathione is the most abundant intracellular antioxidant in the human body, essential for neutralizing free radicals, liver detoxification, and immune cell function.

Mechanism of Action

Functions as the primary substrate for liver detoxification enzymes, directly scavenges free radicals, regenerates vitamins C and E, and inhibits melanin production for skin brightening.

Injection

Administered intramuscularly

Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.

Benefits

Detox

Supports your liver's ability to process and eliminate toxins, medications, and metabolic waste from your body.

Immune Function

Fuels your immune cells so they can activate and respond effectively to infections and illness.

Skin Brightness

Brightens and evens skin tone by reducing melanin production and neutralizing oxidative skin damage.

Energy

Reduces oxidative stress that drains cellular energy, supporting improved vitality and reduced fatigue.

Gut & Liver Health

Reinforces the intestinal mucosal barrier to prevent leaky gut and reduce systemic inflammation. Replenishes hepatic glutathione stores that power the liver's detox pathways and protect the liver-gut axis from oxidative damage.

Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.

IM Injection Protocol

Glutathione (GSH)

The body’s most powerful intracellular antioxidant — administered intramuscularly at 200–600 mg per week to drive deep detoxification, protect the liver, heal the gut lining, and brighten skin from within.

L-Glutathione (Reduced)
C₁₀H₁₇N₃O₆S
200–600 mg IM
Once Weekly
Tripeptide Composition
Glutathione is assembled from three amino acids. The cysteine residue carries the reactive thiol (–SH) group — the functional core that neutralizes toxins, free radicals, and oxidative byproducts throughout every organ system.
GLU
Glutamate
–
CYS —SH
Cysteine (active site)
–
GLY
Glycine
IM Dose Range
200–600 mg
Administered once weekly via IM injection
Primary Synthesis Site
Liver
Hepatocytes maintain highest GSH concentration in the body
IM Onset
15–30 min
Active window 4–6 hours post-injection
Rate-Limiting Step
Cysteine
Cysteine availability limits GSH biosynthesis rate
Biochemical Mechanism
The GSH ↔ GSSG Redox Cycle
GSH
Reduced Glutathione
Active antioxidant form
Thiol –SH group intact
Donates electrons to ROS
→
Oxidation
Neutralizes ROS
GSSG
Oxidized Glutathione
Spent form after ROS
neutralization
Two GSH linked by disulfide
→
Reduction
via GR + NADPH
GR + NADPH
Glutathione Reductase
Regenerates GSH from GSSG using NADPH as electron donor
→
Recycled
back to active
GSH
Regenerated GSH
Restored active form
Ready for next cycle
Cycle repeats continuously
IM Protocol Metrics

By the Numbers

Key clinical parameters for intramuscular glutathione administered weekly — the preferred route for sustained detoxification, liver support, gut healing, and skin brightening.

Weekly IM Dose
200–600
mg per IM injection
once weekly protocol
IM Onset
15–30
minutes to systemic effect
active window 4–6 hours
Liver GSH Level
1–10 mM
normal hepatic GSH conc.
IM injection replenishes stores
Skin Response
4–8 wk
weeks to visible brightening
with consistent weekly dosing
Pharmacological Profile

Effect Profile & Cumulative Response

Glutathione’s potency across four clinical target areas, and the progressive cumulative benefit of weekly IM dosing over time.

Radar Analysis
Clinical Domain Coverage
Detox Liver Gut Skin Antioxidant Recovery
Cumulative Response
Clinical Effect Over Weekly IM Dosing
Week 1
Week 4
Week 8
DETOX (PHASE II LIVER)
Wk 1
55%
Wk 4
80%
Wk 8
96%
LIVER PROTECTION
Wk 1
50%
Wk 4
76%
Wk 8
92%
GUT LINING REPAIR
Wk 1
40%
Wk 4
68%
Wk 8
85%
SKIN BRIGHTNESS
Wk 1
30%
Wk 4
62%
Wk 8
88%
IM Pharmacokinetics
What Happens After Your Weekly IM Injection
0 min 30 min 1 hr 2 hr 3 hr 4 hr 5 hr 6 hr
Onset
Absorbed into bloodstream (15–30 min)
Peak
Peak plasma — liver & tissue uptake
Active
4–6 hr active window — detox, gut repair, skin & liver loading
Clinical Outcomes

What Weekly IM Glutathione Delivers

Four core clinical targets — detoxification, liver protection, gut healing, and skin brightening — driven by weekly intramuscular delivery directly into systemic circulation.

Deep Detoxification
Drives Phase II hepatic detoxification via glutathione-S-transferase conjugation. Binds and neutralizes heavy metals, environmental toxins, alcohol metabolites, pesticides, and pharmaceutical byproducts — marking them for biliary excretion. Weekly IM dosing maintains elevated GSH stores that oral supplements cannot replicate.
DetoxPhase II
Liver Protection
Hepatocytes maintain the highest GSH concentration of any cell in the body. IM glutathione replenishes hepatic stores depleted by alcohol, medications, processed foods, and oxidative stress. Protects against lipid peroxidation, inflammatory liver injury, and NASH progression. Supports recovery of AST and ALT levels in patients with elevated liver enzymes.
LiverHepatoprotective
Gut Lining Repair
GSH is highly concentrated in intestinal epithelial cells where it protects the mucosal barrier from oxidative damage, inflammation, and permeability. Depleted glutathione contributes to leaky gut, food sensitivities, and intestinal inflammation. Weekly IM administration restores intracellular GSH levels in the gut wall, supporting tight junction integrity and mucosal healing.
GutMucosal Barrier
Skin Brightening
Inhibits tyrosinase — the enzyme responsible for converting tyrosine into melanin. Shifts melanin production from dark eumelanin toward lighter phaeomelanin, reducing hyperpigmentation, dark spots, melasma, and uneven skin tone. Clinical brightening effect typically observed within 4–8 weeks of consistent weekly IM dosing.
SkinTyrosinaseAnti-Pigmentation
Oxidative Stress Reduction
GSH is the first line of defense against reactive oxygen species (ROS) generated by metabolic activity, toxin exposure, inflammation, and chronic disease. Neutralizes hydrogen peroxide, lipid peroxides, and free radicals before they cause cellular membrane damage, protein oxidation, and mitochondrial dysfunction across all organ systems.
AntioxidantROS
Cellular Energy & Recovery
Mitochondria require adequate GSH to maintain the electron transport chain and protect against oxidative membrane damage. Low GSH accelerates cellular aging and impairs energy production. Weekly replenishment via IM supports mitochondrial efficiency, reduces systemic inflammation, and improves overall vitality and post-exertion recovery.
MitochondriaRecovery
Medical Supervision Required. Intramuscular glutathione must be prescribed and administered under the supervision of a licensed medical provider. Standard IM dosing is 200–600 mg once weekly, individualized based on clinical goals and patient response. Patients with known sensitivity to sulfur-containing compounds or glucose-6-phosphate dehydrogenase (G6PD) deficiency should be screened prior to initiation. Not intended to diagnose or treat any disease. Individual results vary based on oxidative burden, baseline GSH levels, lifestyle factors, and frequency of administration.

Simple. Medical.

Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.

Provider evaluation

A licensed medical provider reviews your intake to determine the safest, personalized treatment.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, & biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.

What Patients Are Experiencing

"Skin tone is visibly brighter and more even after 8 weekly injections. Friends noticed without me saying anything."

— Aisha M. *

"My energy during periods of high stress is noticeably better since starting glutathione. Recovery between workouts improved too."

— Chris T. *

"Post-illness fatigue resolved faster than usual. My provider added glutathione and the difference was clear."

— Laura B. *

*Individual experiences may vary. Not all patients will have the same outcomes.

FAQs

What is Glutathione Injection?

Glutathione Injection is a prescription therapy used for antioxidant and cellular support.

Who should use Glutathione Injection?

Patients seeking support for antioxidant and cellular support may qualify after evaluation by a licensed provider.

Does Glutathione require a prescription?

Yes. Injectable glutathione is a compounded medication requiring a valid prescription from a licensed provider.

What are the possible side effects?

Generally well tolerated. Injection site discomfort is the most common complaint. Rare reports of skin rash or bronchospasm — do not use if you have asthma without provider clearance. Prolonged high-dose use may deplete zinc levels. Seek care immediately for any signs of allergic reaction.

Who should not use Glutathione?

Avoid in patients with known hypersensitivity to glutathione components. Use with caution in patients on chemotherapy, as glutathione may reduce oxidative cytotoxic effects.

Are there any drug interactions?

May reduce effectiveness of certain chemotherapeutic agents. Disclose all medications to your provider, particularly immunosuppressants or oncologic treatments.

Is Glutathione safe if I have a pre-existing medical condition?

Patients with liver disease, autoimmune conditions, or those undergoing cancer treatment require provider clearance before starting injectable glutathione.

Contact Us

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Hours

Monday–Saturday, 10am–8pm ET

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Hours

Monday–Saturday, 10am–8pm ET

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Cellular Level?

Physician-prescribed. Delivered to your door. No clinic visits required.

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Optimize Your Protocol

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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.