Evening / bedtime use only — tretinoin is photolabile and increases UV sensitivity. Cleanse and pat completely dry, then wait 10–15 minutes before applying. Apply a small pea-sized amount in a thin even layer to face and neck, avoiding the immediate eye area and lip margins. The dual tolerability buffering of niacinamide and GHK-Cu typically makes adjustment milder, but a gradual start is recommended — begin every other night for 1–2 weeks, then advance to nightly as tolerated. Note: GHK-Cu Acetate has a characteristic blue hue — any visible tint typically resolves within seconds of application. Daily broad-spectrum SPF 30+ in the morning is mandatory.

Contraindicated in pregnancy (tretinoin is teratogenic) and breastfeeding. Patients with hormone-sensitive malignancies should discuss estriol use with their oncologist. Patients with known copper or copper peptide sensitivity should not use this product. Do not combine with other retinoids, AHAs/BHAs, or benzoyl peroxide (which inactivates tretinoin on contact) without provider direction. High-dose zinc or copper-chelating topicals may interfere with GHK-Cu activity. This is a compounded prescription product — not FDA-approved.

Store at room temperature (68°F–77°F), away from direct heat, humidity, and light. Keep container tightly closed. Tretinoin is light-sensitive — store in original packaging away from sunlight. Do not freeze. Keep out of reach of children. Use before the labeled expiration date.