Sermorelin Injection

Sermorelin acetate is a synthetic peptide comprising the first 29 amino acids of growth hormone-releasing hormone (GHRH). It stimulates the pituitary to release the body's own growth hormone naturally — preserving the physiological pulsatility and feedback controls that direct GH replacement bypasses.

Overview

Growth hormone follows a well-documented age-related decline — beginning in the third decade at roughly 14% per decade. Sermorelin is prescribed to restore a more youthful pattern of pulsatile GH release and support downstream IGF-1 production, addressing the body composition, recovery, sleep, and vitality changes associated with somatopause.

Mechanism of Action

GHRH Receptor Binding

Sermorelin binds to GHRH receptors on somatotroph cells in the anterior pituitary, triggering the synthesis and pulsatile release of growth hormone — the same signal the hypothalamus uses naturally.

Pulsatile GH Release

Unlike direct GH injections, sermorelin-stimulated release remains subject to somatostatin regulation — preserving natural pulsatility and preventing receptor desensitization. The pituitary cannot release more GH than it is capable of producing.

IGF-1 Production

GH released by sermorelin travels to the liver, stimulating IGF-1 — the primary downstream mediator of GH's anabolic effects: muscle protein synthesis, lipolysis, collagen formation, and cellular regeneration.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

Administration

Sermorelin is supplied as a lyophilized powder, reconstituted with bacteriostatic water, and administered subcutaneously. Bedtime administration is preferred to align with the body's natural nocturnal GH pulse. Dose and frequency are determined entirely by your prescribing provider based on baseline IGF-1 levels and treatment goals.

Precautions

Adult sermorelin use is off-label — not FDA-approved. Baseline labs including IGF-1, fasting glucose, and thyroid panel are required before starting. Contraindicated in active malignancy, elevated baseline IGF-1, active intracranial pathology, pregnancy, and breastfeeding. GH can transiently impair insulin sensitivity — patients with diabetes require careful monitoring. Disclose all medications and health conditions to your provider.

Storage

Store unreconstituted vials refrigerated at 36°F–46°F (2°C–8°C), protected from light. Do not freeze. Once reconstituted, refrigerate and use within 28 days. Discard if cloudy or discolored. Keep out of reach of children.

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