TruAge

By: TruDiagnostic

Test Type: Epigenetic biological age assessment

Sample Type: At-home blood spot (finger prick) C

ollection: Single collection day; at-home kit

Turnaround Time: Approximately 21 days from lab receipt

Price: Starting at $375

Category: Longevity / Biological Age / Epigenetics / Preventive Health

This test is ordered through a licensed healthcare provider. Results are delivered to your provider for clinical interpretation and integration into your personalized health plan.

Overview

Your chronological age — the number on your birthday — is a poor proxy for how your body is actually aging. Two people born in the same year can have dramatically different physiological profiles: one with the cellular health, inflammatory burden, immune function, and organ system vitality of someone a decade younger; the other showing biological wear that tracks well ahead of the calendar. Chronological age cannot distinguish between them. Biological age can.

The TruAge Complete Collection by TruDiagnostic is the most comprehensive commercially available epigenetic biological age assessment, measuring over 75 longevity biomarkers from a single at-home blood spot collection to produce a detailed, multi-dimensional picture of how your body is aging at the cellular and molecular level. It goes beyond asking how old you are and answers the questions that actually matter for health and longevity: How fast is your biological clock ticking right now? Are specific organ systems aging ahead of or behind the rest of your body? Is chronic inflammation accelerating your aging trajectory? How does your immune health, blood sugar regulation, and cellular maintenance capacity compare to optimal? And — critically — where is the most meaningful opportunity to intervene?

The TruAge Complete Collection is anchored by two of the most scientifically advanced aging algorithms ever developed: OMICm Age, created by TruDiagnostic in collaboration with Harvard University and trained on multiomic biological data rather than chronological age alone; and DunedinPACE, the only publicly available aging algorithm validated against real-world longitudinal health outcomes — measuring not just where your biological age sits today, but the speed at which you are aging every year.

Biomarkers Assessed

Average Telomere Length

Mitotic Clock

Immune Cell Deconvolution

DunedinPACE: Pace of Aging

Weight Loss Response

Smoking Risk

Inflammation Markers (DNAmCRP & DNAmIL-6)

OMICmAge: Biological Age

Physical Fitness Age

SYMPHONYAge: Organ Systems

Type 2 Diabetes Risk

Alcohol Consumption Risk

What's Included: The Complete Report Suite

OMICm Age — Biological Age (Harvard-Developed)

OMICm Age is the most advanced biological age algorithm currently available, developed by TruDiagnostic in collaboration with Harvard University. Unlike earlier epigenetic clocks trained on chronological age — which optimized for matching calendar years — OMICm Age was trained on multiomic biological data: genomic, transcriptomic, proteomic, and metabolomic inputs that collectively reflect the true physiological state of the organism. The result is an algorithm that doesn't just estimate how old your biology looks — it provides novel insights into the specific biological processes driving accelerated or decelerated aging in your cells. For patients with biological ages that differ meaningfully from their chronological age, OMICm Age begins to explain why.

DunedinPACE — Speed of Aging

DunedinPACE is the only publicly available aging algorithm developed not from cross-sectional age comparisons but from the longitudinal Dunedin Study — a 50-year cohort study initiated in 1972 in Dunedin, New Zealand, following over 1,000 individuals from birth through adulthood with continuous measurement of physiological health variables. This training process gives DunedinPACE a fundamentally different and clinically more powerful output than other aging clocks: rather than estimating your biological age at a single point in time, it measures your current pace of aging — how many biological years you are accumulating for every calendar year that passes.

SYMPHONYAge — 11 Organ System Ages

SYMPHONYAge disaggregates biological age into the eleven major organ systems — brain, heart, lung, liver, kidney, metabolic, immune, inflammatory, musculoskeletal, hormonal, and more — providing individual biological age estimates for each. This organ-level resolution reveals the heterogeneity of aging that whole-body averages obscure: a patient whose overall biological age looks favorable may have a specific organ system aging significantly ahead of the rest of their body, representing a targeted clinical vulnerability that a single aggregate score would miss entirely. SYMPHONYAge allows for precision intervention — directing lifestyle, supplementation, and therapeutic strategies toward the specific systems where the biological aging burden is greatest.

Telomere Length Report

Telomeres are the protective nucleotide caps at the ends of chromosomes that shorten with each cell division and with exposure to oxidative stress, inflammation, and chronic psychological stress. Telomere length is one of the most established cellular biomarkers of aging and is associated with risk for age-related diseases, immune function, and all-cause mortality. The TruAge Telomere Length Report provides absolute telomere length measurement and comparison to age-matched population norms — establishing a key cellular aging baseline and a trackable metric for longitudinal monitoring of interventions

Immune Report — Immune Cell Deconvolution

The immune system is one of the most sensitive biological systems to aging — and one of the most important modulators of aging rate. The Immune Report uses DNA methylation-based immune cell deconvolution to characterize the composition and functional profile of circulating immune cells, including the CD4/CD8 T cell ratio — an established marker of immune aging (immune senescence) that is predictive of infection susceptibility, inflammatory disease risk, and all-cause mortality in older populations. Understanding the immune aging profile guides targeted interventions in sleep, stress, nutrition, and immunological support.

Inflammation Report — DNAmCRP and DNAmIL-6

Chronic low-grade inflammation — increasingly referred to as "inflammaging" — is one of the primary biological mechanisms linking accelerated biological aging to age-related diseases including cardiovascular disease, neurodegeneration, metabolic syndrome, and certain cancers. The Inflammation Report provides epigenetic estimates of C-reactive protein (DNAmCRP) and interleukin-6 (DNAmIL-6) — two of the most clinically important inflammatory biomarkers — derived from DNA methylation data, providing an integrated biological signal of systemic inflammatory burden that is independent of transient acute-phase fluctuations that can confound standard blood inflammatory markers.

Type 2 Diabetes Risk Report

DNA methylation patterns encode meaningful information about metabolic health and blood sugar regulation. The Type 2 Diabetes Risk Report provides an epigenetic assessment of metabolic risk — offering a biological-age-informed lens on cardiometabolic vulnerability that complements standard fasting glucose and HbA1c measurements and can reveal underlying metabolic aging before conventional biomarkers become abnormal.

Physical Fitness Age Report

Cardiorespiratory fitness and physical conditioning are among the most powerful modulators of biological aging rate — and the Fitness Age Report provides an epigenetic estimate of physiological fitness age, independent of reported exercise behavior. This allows objective assessment of the biological imprint of physical conditioning and recovery capacity, providing both a baseline and a sensitive outcome measure for exercise and recovery interventions.

Mitotic Clock Report

The Mitotic Clock tracks cumulative cell division history across tissue types — a biological record of cellular replication burden that reflects tissue turnover rates, regenerative demand, and certain cancer risk signals. This clock provides complementary aging information to the epigenetic methylation-based clocks, capturing a distinct dimension of cellular aging biology.

Smoking and Drinking Report

DNA methylation carries durable biological signatures of tobacco and alcohol exposure — signatures that persist for years after behavioral changes and that reflect cumulative lifetime exposure rather than current behavior. These reports provide objective biological evidence of the epigenetic burden of prior or ongoing substance use, independent of self-report, and contextualize other aging findings in patients with relevant histories.

Weight Loss Response Report

Epigenetic data encodes meaningful individual variation in metabolic response — including differential capacity for weight loss in response to dietary and lifestyle intervention. The Weight Loss Response Report provides a biological prediction of individual weight loss responsiveness, allowing personalized calibration of metabolic intervention strategies.

🧬 CLIA-Certified Laboratory • 🧬 Advanced DNA Methylation Epigenetic Testing • 📊 120,000+ Reference Samples • 🔒 HIPAA Compliant

Your Results

Clear, Actionable Results You Can Actually Use

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Biological Age & Aging Pace

See how your biological age compares to your chronological age and whether your body is aging faster or slower than expected — giving you clear insight into your long-term health trajectory.

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Detailed Epigenetic Health Breakdown

Your report analyzes DNA methylation markers to evaluate key aging systems including immune function, inflammation, metabolic health, and cellular resilience.

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Advanced Epigenetic Testing by TruDiagnostic

Powered by cutting-edge DNA methylation analysis and peer-reviewed epigenetic clocks, providing one of the most advanced biological age assessments available today.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

How It Works

Step 1 — Order and Kit Delivery Your provider orders the TruAge Complete Collection through the [Pharmacy Name] / Rupa Health portal. Your at-home blood spot collection kit is shipped directly to you.

Step 2 — Registration Before collecting your sample, register your kit at www.trudiagnostic.com/register or via the QR code included in your kit. Registration is required for analysis.

Step 3 — Sample Collection Hydrate well for 24 hours before collection. Continue taking all medications and supplements as usual — no fasting or discontinuation required. On collection day:

Clean a fingertip with the provided alcohol wipe

Use the included lancet to produce a small blood drop

Allow drops of blood to saturate the designated collection circles on the card

Air dry the card for a minimum of 3 hours

Step 4 — Return Shipping Place the dried card in the provided biohazard bag, seal it in the return envelope, and ship via USPS — ideally the same day as collection, or refrigerate until shipping.

Step 5 — Results and Consultation Results are typically available to your provider approximately 21 days after the laboratory receives your sample. Your provider will review your complete report suite with you, contextualize your findings within your overall health picture, and develop targeted intervention recommendations based on your specific biological age profile.

Who Should Consider the TruAge Complete Collection

The TruAge Complete Collection is appropriate for anyone motivated to understand and actively manage their biological aging trajectory. It is particularly valuable for:

Longevity-focused individuals who want objective biological data — rather than symptom-based inference — to guide their optimization strategies across sleep, exercise, nutrition, stress management, and supplementation.

Patients with a personal or family history of cardiometabolic disease, cognitive decline, or cancer who want to understand their current biological aging burden and identify the specific systems where proactive intervention is most warranted.

Patients already engaged in anti-aging protocols — whether lifestyle-based, hormonal, peptide, or pharmaceutical — who want to objectively measure whether their interventions are producing measurable biological age improvement rather than relying on subjective assessment alone. DunedinPACE's sensitivity to dynamic physiological change makes it an ideal longitudinal tracking tool for protocol optimization.

Individuals who suspect their biological age does not match their chronological age — whether they feel significantly older or younger than their years and want to understand what the biology actually shows.

Healthcare providers practicing functional, integrative, or longevity medicine who want the most comprehensive available biological age data platform to anchor personalized clinical decision-making.

Anyone motivated to make lifestyle changes who needs an objective, compelling biological baseline to inform and sustain behavioral commitment — because knowing your DunedinPACE score is accelerating is a profoundly different kind of motivation than general health awareness.

Do I need to fast before collecting my sample?

No. Continue all medications and supplements as usual. Hydrate well for 24 hours before collection — good hydration improves blood flow and collection ease. No dietary changes or fasting are required.

How is this different from a standard blood panel?

Standard blood panels measure circulating biochemical markers — cholesterol, glucose, hormones, inflammatory proteins — at a single point in time. The TruAge Complete Collection measures the epigenetic programming of your cells: the cumulative record of how your biology has responded to your lifetime of exposures, habits, stressors, and health history. It answers a different and complementary question — not what your blood chemistry looks like today, but how old your cellular machinery has become and how fast it is aging.

Can I retest to track progress?

Yes — and retesting is one of the most valuable applications of the TruAge platform. DunedinPACE in particular is specifically designed as a sensitive longitudinal tracking tool. Many patients retest at 6–12 month intervals to objectively assess whether lifestyle, supplement, hormonal, or peptide interventions are producing measurable biological age improvement.

Will my results change with lifestyle changes?

Yes. Epigenetic marks are not fixed — they are dynamic and respond to changes in diet, exercise, sleep, stress, body composition, and therapeutic interventions. This is precisely what makes biological age testing valuable as an outcome measure: it provides objective evidence of whether your interventions are working at the cellular level, not just on the scales or on standard lab panels.

How are results delivered?

Results are delivered to your ordering provider approximately 21 days after the laboratory receives your sample. Your provider will review the complete report suite with you in a follow-up consultation and develop personalized recommendations based on your findings.

The information and products provided on this website are for educational and wellness purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Individual results may vary, and products carry potential risks and side effects. Certain products may not be evaluated by the U.S. Food and Drug Administration (FDA) unless explicitly stated. Services are provided by licensed physicians and nurse practitioners in states where they are authorized to practice, including California, Florida, Nevada, and other participating states. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, and Telehealth Consent. You must be 18 years of age or older to use this service.