Anti-Inflammatory + Brain + Immune boost
Vasoactive Intestinal Peptide Nasal Spray
VIP is one of the most powerful anti-inflammatory molecules in your nervous and immune system. One spray supports full-body inflammation control, immune regulation, deeper sleep, and neurological protection.
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Overview
Pharmacology
Vasoactive intestinal peptide (VIP) is a 28-amino acid neuropeptide and hormone with pleiotropic signaling roles across the nervous, immune, and cardiovascular systems. VIP is produced by neurons in the gut, lung, and CNS, and acts on VPAC1 and VPAC2 receptors expressed in immune cells, smooth muscle, endothelial cells, and throughout the brain. VIP declines in chronic inflammatory and neurodegenerative conditions. Intranasal delivery provides direct mucosal absorption and olfactory pathway access to the CNS, bypassing the blood-brain barrier limitation that restricts systemic peptide delivery to central targets.
Mechanism of Action
VIP binds VPAC1 and VPAC2 G-protein-coupled receptors to activate adenylyl cyclase and increase intracellular cAMP, producing vasodilation in pulmonary and systemic vasculature through smooth muscle relaxation. In immune cells, cAMP elevation suppresses NF-kB signaling, reducing pro-inflammatory cytokine production including TNF-alpha, IL-6, and IL-12 while promoting anti-inflammatory IL-10 and regulatory T-cell differentiation. VIP acts as a neurotransmitter and neuromodulator in the CNS, influencing circadian rhythm regulation through the suprachiasmatic nucleus, supporting neuronal survival through anti-apoptotic MAPK and PI3K/Akt signaling, and modulating autonomic tone. In the lung, VIP-mediated bronchial smooth muscle relaxation and mucosal secretion regulation contributes to airway patency and mucociliary defense.
Nasal Spray
Administered intranasally for direct delivery to the central nervous system.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Anti-Inflammatory
Shuts off the inflammatory signals driving chronic fatigue, brain fog, joint pain, and accelerated aging - calming your immune system at the source.
Blood Flow & Circulation
Relaxes blood vessel walls to improve circulation, oxygen delivery, and tissue perfusion throughout the body.
Brain Protection
Activates your neurons' built-in survival pathways — protecting against oxidative stress and the neurological inflammation that accelerates with age.
Sleep & Circadian Rhythm
Regulates your body's internal clock, supporting deeper sleep stages and keeping your hormonal rhythms running on schedule.
Immune Balance
Shifts your immune environment away from overactive inflammatory states toward a calm, regulated response — without suppressing immunity entirely.
Biotoxin & CIRS Recovery
Depleted in Chronic Inflammatory Response Syndrome, VIP is the final step of the Shoemaker Protocol — used after biotoxin removal and MARCoNS eradication to restore neuroendocrine signaling, normalize elevated pulmonary artery pressure, and support recovery of MSH and ADH dysregulation downstream of biotoxin driven inflammation.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
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Provider evaluation
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Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
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FAQs
Does VIP Nasal Spray require a prescription?
Yes. This is a compounded intranasal peptide preparation requiring a valid prescription from a licensed provider.
What are the possible side effects?
Mild transient flushing, nasal irritation, or headache may occur following administration due to VIP's vasodilatory activity. Blood pressure may decrease transiently in sensitive patients; those with baseline hypotension should be monitored. Nasal congestion or mild rhinorrhea at the application site is occasionally reported.
Who should not use VIP Nasal Spray?
Patients with known hypersensitivity to vasoactive intestinal peptide or peptide components should not use this product. Patients with symptomatic hypotension or on antihypertensive medications should use with provider guidance given VIP's vasodilatory activity. Use during pregnancy or breastfeeding requires provider evaluation.
Are there any drug interactions?
VIP's vasodilatory mechanism may produce additive blood pressure reduction in patients on antihypertensive agents, alpha-blockers, or PDE5 inhibitors; concurrent use requires provider guidance. VIP's immune-modulating activity may interact with immunosuppressive regimens; patients on biologics or immunosuppressants should disclose this to their provider before starting.
Is VIP Nasal Spray safe if I have a pre-existing medical condition?
Patients with cardiovascular disease, symptomatic hypotension, or pulmonary hypertension should discuss use with their provider given VIP's vasodilatory and pulmonary effects. Patients with autoimmune conditions on immunosuppressive therapy require provider coordination given VIP's immune-modulating activity. Routine blood pressure monitoring is recommended at initiation.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.