Longevity + B Vitamin
Niagen
A parenteral nicotinamide riboside formulation delivering NAD+ precursor directly into circulation to support cellular energy production, mitochondrial function, and healthy aging at the molecular level.
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Overview
Pharmacology
Niagen is nicotinamide riboside (NR), a bioavailable form of vitamin B3 that serves as a direct precursor to NAD+ (nicotinamide adenine dinucleotide). NAD+ is an essential coenzyme in every living cell, required for mitochondrial ATP production, DNA repair, and the activation of sirtuins, the longevity-associated protein deacetylases. Injectable delivery bypasses GI absorption variability to deliver therapeutic NR concentrations directly to plasma.
Mechanism of Action
NR enters cells via nucleoside transporters and is phosphorylated by NR kinases (NRK1/2) to form nicotinamide mononucleotide (NMN), which is then adenylated by NMNAT enzymes to produce NAD+. Elevated intracellular NAD+ activates SIRT1 and SIRT3 sirtuins, which regulate mitochondrial biogenesis, fatty acid oxidation, and genomic stability. NAD+ also serves as substrate for PARP enzymes involved in DNA strand break repair, and for CD38/CD157 ectoenzymes involved in calcium signaling and immune function. NAD+ declines significantly with age, and NR supplementation restores NAD+ pools in a dose-dependent manner.
Injection
Administered subcutaneously as directed by your provider.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
NAD+ Restoration
Directly replenishes intracellular NAD+ pools that decline with age, restoring cofactor availability for hundreds of NAD+-dependent enzymatic reactions.
Mitochondrial Support
Activates SIRT3 and supports mitochondrial biogenesis, improving cellular energy metabolism in high-demand tissues including cardiac and neural cells.
DNA Repair
Elevated NAD+ provides substrate for PARP enzymes that repair DNA strand breaks, supporting genomic integrity and reducing age-associated cellular damage.
Sirtuin Activation
SIRT1 activation by restored NAD+ regulates metabolic adaptation, inflammation, and stress resistance pathways associated with longevity biology.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
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Medical intake
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Provider evaluation
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Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
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FAQs
What is Niagen?
Niagen is a prescription therapy used for cellular energy support.
Who should use Niagen?
Patients seeking support for cellular energy support may qualify after evaluation by a licensed provider.
Does Niagen Injection require a prescription?
Yes. Injectable ubidecarenone is a compounded pharmaceutical preparation requiring a valid prescription from a licensed provider.
What are the possible side effects?
Injection site reactions including mild soreness or bruising are most common. High-dose NR may cause transient flushing, nausea, or mild GI discomfort. Systemic adverse effects at therapeutic doses are rare.
Who should not use Niagen Injection?
Avoid use in patients with active or prior cancer, pregnancy or breastfeeding, or rheumatoid arthritis. NAD+ supports cellular proliferation pathways and requires oncology clearance in cancer history. Not for patients with known hypersensitivity to nicotinamide riboside.
Are there any drug interactions?
Use with caution in patients on insulin or oral hypoglycemic agents, as NR may modestly affect glucose metabolism. Patients on anticoagulants such as warfarin should disclose this to their provider. No major pharmacokinetic drug interactions are currently established.
Is Niagen Injection safe if I have a pre-existing medical condition?
Patients with diabetes require blood glucose monitoring given NR's effect on insulin sensitivity pathways. Patients with autoimmune conditions including rheumatoid arthritis should avoid use. Provider evaluation is required before starting in patients with any chronic or active medical condition.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.