Energy + Brain Focus
NAD+ Nasal Spray
This intranasal formulation delivers NAD+ directly through your nasal passages into your bloodstream and brain. Feel the difference in your energy, mental clarity, and recovery — at the cellular level.
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Overview
Pharmacology
Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme in every living cell, functioning as the primary electron carrier in oxidative phosphorylation and as the obligate substrate for sirtuin deacetylases and PARP DNA repair enzymes. NAD+ levels decline substantially with age, metabolic disease, and chronic oxidative stress, reducing mitochondrial energy production, impairing DNA damage response, and accelerating cellular aging. Nasal delivery provides direct access to systemic circulation and bypasses GI degradation, supporting higher bioavailability than oral precursors at therapeutic concentrations.
Mechanism of Action
NAD+ serves as a hydride transfer coenzyme in the mitochondrial electron transport chain, accepting electrons from NADH in Complexes I and II to drive ATP synthesis via oxidative phosphorylation. As the obligate substrate for sirtuin enzymes (SIRT1-SIRT7), NAD+ enables deacetylation of histones and transcription factors regulating mitochondrial biogenesis, inflammation, and stress resistance through PGC-1alpha and FOXO pathways. NAD+ is consumed by PARP-1 during DNA single-strand break repair, linking its availability directly to genomic integrity. CD38 ectoenzyme activity is the primary driver of NAD+ decline with aging.
Nasal Spray
Administered intranasally for direct delivery to the central nervous system.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Cellular Energy
NAD+ activates sirtuins — the proteins your body uses to repair cells, regulate inflammation, and slow the biological clock. Higher NAD+ means your cells are better equipped to repair damage, reduce aging signals, and keep functioning at their peak.
Brain Focus & Mental Clarity
Delivered directly through the nasal passage, NAD+ reaches your brain faster than any oral supplement. Your brain is one of the highest energy-consuming organs in the body — restoring its NAD+ supply supports sharper thinking, faster recall, and sustained mental performance.
DNA Repair
Every day your DNA sustains damage from stress, toxins, and aging. NAD+ is what powers your body's repair system. More NAD+ means faster repair and less accumulated damage over time.
Energy
NAD+ is what your mitochondria use to produce ATP - the energy currency your body runs on. Restoring depleted NAD+ levels means your cells can generate energy the way they did when you were younger. Less fatigue, more output.
Anti-Aging
NAD+ decline is one of the most well-documented drivers of aging. Replenishing it addresses the root cause — not the symptoms — supporting the mitochondrial health, cellular repair, and hormonal regulation that keep you feeling and functioning younger.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
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Provider evaluation
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Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
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FAQs
What is NAD Nasal Spray?
NAD Nasal Spray is a prescription therapy used for cognitive and energy support.
Who should use NAD Nasal Spray?
Patients seeking support for cognitive and energy support may qualify after evaluation by a licensed provider.
Does NAD+ Nasal Spray require a prescription?
Yes. This is a compounded intranasal preparation requiring a valid prescription from a licensed provider.
What are the possible side effects?
Mild nasal irritation, congestion, or transient flushing are the most commonly reported effects. Some patients report a brief sensation of warmth or mild headache following administration, consistent with effects commonly reported with NAD+ administration. These effects are generally short-lived.
Who should not use NAD+ Nasal Spray?
Patients with known hypersensitivity to nicotinamide or NAD+ components should not use this product. Patients with active malignancy should consult their oncologist before use, as NAD+ supports cellular proliferation pathways including PARP and sirtuin activity. Use during pregnancy or breastfeeding requires provider evaluation.
Are there any drug interactions?
NAD+ does not have established clinically significant drug interactions at therapeutic intranasal doses. Concurrent use of PARP inhibitors (e.g., olaparib) used in oncology may reduce the efficacy of either agent; patients on PARP inhibitor therapy should consult their oncologist before use.
Is NAD+ Nasal Spray safe if I have a pre-existing medical condition?
Patients with a history of hormone-sensitive or proliferative malignancy require oncological clearance before initiating NAD+ therapy given its role in cellular energy and repair pathways. Patients with severe hepatic impairment should discuss use with their provider. Routine monitoring is not required in otherwise healthy patients.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.