Skincare + Hyperpigmentation
Luminance
A six-active brightening formula combining proven depigmentation agents with antioxidant polyphenols for comprehensive treatment of hyperpigmentation and uneven skin tone.
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Overview
Azelaic Acid + Hydrocortisone + Hydroquinone
Kojic Acid + Green Tea EGCG + Resveratrol
Luminance addresses hyperpigmentation through simultaneous tyrosinase inhibition, melanin transfer disruption, anti-inflammatory control, and antioxidant defense. The inclusion of green tea EGCG and resveratrol provides additional free radical protection and synergistic brightening activity alongside the depigmentation actives.
Mechanism of Action
Hydroquinone inhibits tyrosinase, the rate-limiting enzyme in melanin biosynthesis. Kojic acid chelates copper at the tyrosinase active site for additive tyrosinase inhibition. Azelaic acid reduces abnormal melanocyte proliferation and has direct tyrosinase-inhibitory activity. Hydrocortisone suppresses the post-inflammatory cytokine environment that drives reactive hyperpigmentation. EGCG and resveratrol scavenge reactive oxygen species that upregulate melanogenesis signaling.
Topical Application
Applied to affected areas as directed.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Brightening
Hydroquinone and kojic acid provide dual-mechanism tyrosinase inhibition for more complete melanin synthesis suppression.
Anti-Inflammatory
Hydrocortisone reduces post-inflammatory hyperpigmentation by suppressing the cytokine cascade that activates excess melanocyte activity.
Antioxidant Defense
EGCG and resveratrol neutralize reactive oxygen species that upregulate melanogenesis and contribute to oxidative skin aging.
Skin Tone
Multi-pathway depigmentation coverage addresses melasma, post-inflammatory hyperpigmentation, and solar lentigines simultaneously.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
Simple. Medical. Personalized.
Medical intake
Answer a few online questions about your health history, lifestyle, and goals. No clinic visits required.
Provider evaluation
A licensed medical professional reviews your intake and determines the safest, personalized treatment.
Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, and biology.
Ongoing support
Stay connected with your care team for follow-ups, adjustments, and expert answers 100% online.
All eligibility is reviewed by a licensed medical professional.
FAQs
What is Luminance?
Luminance is a prescription therapy used for skin brightness support.
Who should use Luminance?
Patients seeking support for skin brightness support may qualify after evaluation by a licensed provider.
Does Luminance require a prescription?
Yes. This formula contains hydroquinone and hydrocortisone, both requiring a valid prescription from a licensed provider.
What are the possible side effects?
Hydroquinone may cause mild irritation, erythema, or paradoxical darkening with prolonged use. Hydrocortisone may cause skin thinning with extended application. Azelaic acid may cause transient tingling or dryness.
Who should not use Luminance?
Not for patients with known hypersensitivity to hydroquinone, hydrocortisone, or any component. Not recommended during pregnancy without provider evaluation.
Are there any drug interactions?
No significant systemic drug interactions are established for topical use at standard concentrations. Concurrent retinoid or alpha-hydroxy acid use may increase irritation and should be discussed with your provider.
Is Luminance safe if I have a pre-existing medical condition?
Patients with diabetes should monitor blood glucose if applying over large body surface areas due to hydrocortisone absorption risk. Patients with a history of ochronosis require provider evaluation before hydroquinone use.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.