Antiparasitic
Ivermectin
Eliminates roundworms and parasites acquired from raw fish, sushi, contaminated water, and soil — while also blocking viral replication in respiratory infections.
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Overview
Ivermectin
Ivermectin is an FDA-approved macrocyclic lactone antiparasitic with a well-established safety profile across decades of clinical use. Primary indications include Strongyloides stercoralis, Onchocerca volvulus, lymphatic filariasis, scabies, and Demodex — conditions where no effective alternative exists or where oral therapy is preferred over topical. Beyond its primary antiparasitic indications, ivermectin has demonstrated broad antiviral activity, anti-inflammatory and immunomodulatory properties, and emerging evidence for longevity-relevant mechanisms including mTOR pathway modulation and senomorphic activity in preclinical models. Ivermectin is metabolized by CYP3A4 in the liver with a half-life of approximately 18 hours and is excreted primarily in feces.
Mechanism of Action
Ivermectin binds glutamate-gated chloride ion channels and GABA-gated chloride channels selectively expressed in invertebrate nerve and muscle cells, increasing membrane permeability to chloride ions and causing hyperpolarization, paralysis, and death of parasites. In mammalian cells, ivermectin does not cross the blood-brain barrier at standard doses due to P-glycoprotein efflux, limiting CNS toxicity. Its antiviral activity involves inhibition of importin alpha/beta-mediated nuclear import of viral proteins, disrupting replication of multiple RNA viruses. Ivermectin also inhibits PAK1 kinase to reduce inflammatory signaling and has demonstrated mTORC1 inhibitory activity in preclinical longevity models, a mechanism shared with rapamycin.
Oral Capsule
Taken orally once daily. No injection required.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Antiparasitic
Kills the roundworms and parasites picked up from sushi, raw fish, beef tartare, contaminated water, and soil. Works by paralyzing and eliminating parasites without affecting your nervous system.
Antiviral
Blocks the pathway viruses use to enter your cells and replicate, with activity documented across multiple RNA virus families.
Anti-Inflammatory
Reduces the inflammatory signals that drive chronic inflammation, supporting immune balance beyond its antiparasitic role.
mTOR Modulation
Activates the same longevity pathway targeted by rapamycin
Kills Roundworms
Targets the roundworm species, including Anisakis simplex (raw fish and sushi), Ascaris lumbricoides and Strongyloides stercoralis (contaminated water and produce), Toxocara (soil-contaminated food and water), and hookworm species acquired through environmental exposure.
Kills Ectoparasites
Eliminates scabies (Sarcoptes scabiei), head lice (Pediculus humanus), and Demodex mites through systemic oral delivery — reaching skin and hair follicles where topical treatments fail to penetrate, clearing infestations at the source rather than at the surface.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
Parasites Eliminated by Ivermectin
Binds glutamate-gated chloride channels in parasite nerve and muscle cells — causing paralysis and death across filarial worms, ectoparasites, and intestinal helminths.
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FAQs
What is Ivermectin?
Ivermectin is a prescription therapy used for prescription antiparasitic support.
Who should use Ivermectin?
Patients seeking support for prescription antiparasitic support may qualify after evaluation by a licensed provider.
Does Ivermectin require a prescription?
Yes. Ivermectin is an FDA-approved prescription medication. A valid prescription from a licensed provider is required.
What are the possible side effects?
Most common effects are GI-related: nausea, diarrhea, and abdominal discomfort. In patients with heavy parasitic burden, Mazzotti-like reactions (fever, rash, swelling) may occur as dying parasites release antigens. Dizziness, somnolence, and pruritus may occur. CNS effects are rare at standard doses in patients without P-glycoprotein deficiency.
Who Should Not Use Ivermectin?
Not for patients with known hypersensitivity to ivermectin. Patients with confirmed or suspected Loa loa infection require specialist evaluation before use due to risk of serious neurological adverse events. Not recommended in pregnancy. Patients with meningitis or conditions that may compromise the blood-brain barrier require provider evaluation.
Are there any drug interactions?
Ivermectin is a CYP3A4 substrate; strong CYP3A4 inhibitors including ritonavir and ketoconazole increase ivermectin exposure significantly. Strong CYP3A4 inducers reduce efficacy. Ivermectin is a P-glycoprotein substrate; P-gp inhibitors including cyclosporine may increase CNS penetration and toxicity risk. Warfarin anticoagulant effect may be enhanced; INR monitoring is recommended.
Is Ivermectin safe if I have a pre-existing medical condition?
Patients with hepatic impairment require provider evaluation given CYP3A4-dependent hepatic metabolism. Patients with P-glycoprotein deficiency (MDR1 mutations) are at increased risk of CNS toxicity and require specialist review. Patients on immunosuppressive therapy should discuss timing with their provider.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.