Hair Growth + DHT Blockade
Hair Restore Extreme Scalp Solution
A selective estrogen receptor modulator (SERM) that blocks estrogen receptor activity in breast and hypothalamic tissue while preserving or stimulating estrogenic activity in bone and the pituitary axis, used in male hormone optimization to manage estrogen-related side effects and restore HPG axis function.
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Overview
Minoxidil + Dutasteride + Finasteride + Tretinoin + Ketoconazole
Hair Restore Extreme combines the most potent topical DHT blockade available with anagen prolongation, penetration enhancement, and antifungal scalp optimization. Dutasteride inhibits both type I and type II 5-alpha reductase isoenzymes for more complete intrafollicular DHT suppression than finasteride alone. Finasteride provides additive type II inhibition. Minoxidil prolongs anagen and increases perifollicular vasodilation. Tretinoin maximizes the scalp penetration of all co-actives. Ketoconazole reduces scalp Malassezia-driven inflammation that accelerates follicular miniaturization.
Mechanism of Action
Dutasteride inhibits both 5-alpha reductase type I (expressed in sebaceous glands and skin) and type II (expressed in follicular dermal papilla), reducing intrafollicular DHT more completely than finasteride alone. Finasteride provides selective type II inhibition, adding to dutasteride's coverage at the primary follicular enzyme. Minoxidil opens ATP-sensitive potassium channels in perifollicular vascular smooth muscle to increase local blood flow and prolongs anagen by stimulating prostaglandin E2 synthesis in dermal papilla cells. Tretinoin increases stratum corneum permeability by reducing corneocyte cohesion and upregulating follicular epithelial cell differentiation, maximizing the transdermal delivery of all co-actives. Ketoconazole inhibits Malassezia furfur fungal colonization and directly inhibits scalp DHT synthesis through weak CYP-mediated steroidogenic inhibition, while reducing the seborrheic inflammatory microenvironment that worsens androgenetic alopecia.
Topical Solution
Applied directly to the scalp daily as directed by your provider.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Maximum DHT Blockade
Dual-isoenzyme 5-alpha reductase inhibition via dutasteride combined with finasteride's type II coverage provides the most complete topical intrafollicular DHT suppression available.
Anagen Prolongation
Minoxidil extends the hair growth phase through potassium channel opening and prostaglandin E2 stimulation in dermal papilla cells, supporting follicular recovery and density improvement.
Penetration Enhancement
Tretinoin disrupts the stratum corneum barrier to maximize the follicular delivery of all four co-actives, increasing their effective tissue concentration at the target.
Scalp Optimization
Ketoconazole reduces Malassezia colonization and scalp DHT synthesis, clearing the inflammatory perifollicular environment that accelerates miniaturization independently of DHT.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
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Medical intake
Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.
Provider evaluation
A licensed medical provider reviews your intake to determine the safest, personalized treatment.
Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
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All eligibility is reviewed by a licensed medical professional
FAQs
Does Hair Restore Extreme require a prescription?
Yes. This formula contains dutasteride, finasteride, and tretinoin, all requiring a valid prescription from a licensed provider.
What are the possible side effects?
Tretinoin may cause scalp dryness, peeling, and photosensitivity. Minoxidil may cause transient shedding in weeks 4 to 8 and adjacent hypertrichosis. Systemic absorption of dutasteride and finasteride from topical application is substantially lower than oral dosing but should be discussed with your provider, particularly for women of childbearing potential.
Who should not use Hair Restore Extreme?
Not for pregnant women or women of childbearing potential due to finasteride and dutasteride teratogenic risk. Not for patients with active scalp infections or known hypersensitivity to any component. Ketoconazole requires provider evaluation in patients with hepatic impairment.
Are there any drug interactions?
Topical finasteride and dutasteride systemic absorption is low, but patients on CYP3A4 inhibitors should disclose this to their provider. Tretinoin increases photosensitivity with concurrent alpha-hydroxy acid or additional retinoid use. Ketoconazole at topical scalp concentrations has minimal systemic drug interaction risk.
Is Hair Restore Extreme safe if I have a pre-existing medical condition?
Patients with hepatic impairment should discuss the ketoconazole and dutasteride components with their provider. Patients with cardiovascular conditions should discuss the minoxidil component. Not recommended in pregnancy under any circumstances due to the teratogenic 5-alpha reductase inhibitors.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.