Natural T + Sperm Production

Gonadorelin

Enclomiphene + Oxytocin Tadalafil + PT-141

A five-in-one troche combining HPG axis testosterone stimulation, central desire activation, bonding hormone enhancement, and reliable erectile vasodilation for the most comprehensive sexual health and hormonal support.

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  • Ships From USA Pharmacy

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  • Licensed Pharmacy

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Overview

Gonadorelin 500 mcg / Enclomiphene 25 mg / Oxytocin 100 IU / Tadalafil 5 mg / PT-141 2 mg

This formula adds PT-141 (bremelanotide) to the four-active gonadorelin, enclomiphene, oxytocin, and tadalafil foundation. PT-141 activates melanocortin-4 receptors in the central nervous system to directly increase sexual desire through brain-level arousal pathways, an entirely different mechanism from the vascular action of tadalafil and the bonding effects of oxytocin. Together the five actives cover hormonal, neurological, vascular, and psychological dimensions of sexual health simultaneously.

Mechanism of Action

Gonadorelin drives pulsatile pituitary LH and FSH release for testicular testosterone production. Enclomiphene amplifies this signal by blocking estrogenic HPG negative feedback. PT-141 activates MC4R receptors in the hypothalamus and limbic system to increase sexual motivation and desire through the central melanocortin arousal pathway, independently of blood flow or genital engorgement. Oxytocin enhances genital sensitivity, emotional bonding, and arousal through central and peripheral receptor activation. Tadalafil inhibits PDE5 to sustain penile vasodilation and reliable erectile response lasting up to 36 hours.

Oral

Dissolve one troche under your tongue before bed

Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.

Benefits

Sexual Health

Five independent mechanisms cover every dimension of sexual response: desire (PT-141), bonding and sensitivity (oxytocin), vasodilation and erection (tadalafil), and hormonal testosterone foundation (gonadorelin and enclomiphene).

Libido

PT-141 activates the brain's own arousal circuitry to restore the actual desire to engage, which vascular medications alone cannot address.

Mood and Stress

Oxytocin and PT-141 together activate complementary central pathways that enhance emotional connection, anticipation, and sexual confidence.

Energy

Gonadorelin and enclomiphene restore the testosterone foundation that supports energy, motivation, and drive beyond the immediate sexual encounter.

Confidence

The most complete available combination addressing desire, arousal, physical response, and hormonal health in one sublingual troche.

Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.

Simple. Medical.

Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.

Provider evaluation

A licensed medical provider reviews your intake to determine the safest, personalized treatment.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, & biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.

All eligibility is reviewed by a licensed medical professional

FAQs

What is Gonadorelin / Enclomiphene / Oxytocin / Tadalafil / PT-141 Troche?

A compounded sublingual troche combining five actives targeting every major dimension of male sexual health and hormonal function simultaneously: central desire (PT-141), bonding and sensitivity (oxytocin), vasodilation (tadalafil), and HPG axis testosterone support (gonadorelin and enclomiphene). Doses are listed on your order form.

Who should use Gonadorelin / Enclomiphene / Oxytocin / Tadalafil / PT-141 Troche?

Men managing multiple overlapping sexual health concerns including low desire, reduced arousal, erectile difficulty, and declining testosterone who want a comprehensive single-product solution. Provider evaluation is required before prescribing.

Does Gonadorelin / Enclomiphene / Oxytocin / Tadalafil / PT-141 Troche require a prescription?

Yes. Gonadorelin, enclomiphene, PT-141, and tadalafil are all prescription-only medications. A valid prescription from a licensed provider is required.

What are the possible side effects?

PT-141: nausea (most common, reduced by taking after a light meal), facial flushing, and transient blood pressure elevation. Tadalafil: headache, flushing, and nasal congestion. Oxytocin: mild nausea or transient blood pressure change. Gonadorelin: mild flushing. Enclomiphene: elevated estradiol and mood variability. Nitrates in any form are an absolute contraindication with tadalafil.

Who Should Not Use Gonadorelin / Enclomiphene / Oxytocin / Tadalafil / PT-141 Troche?

Anyone taking nitrates must not use this product. Not for patients with uncontrolled hypertension, significant cardiovascular disease, primary hypogonadism, hormone-sensitive malignancy, or known hypersensitivity to any component. Not for use in women.

Are there any drug interactions?

Tadalafil with nitrates is an absolute contraindication. PT-141 transiently elevates blood pressure and requires caution with antihypertensive medications. Strong CYP3A4 inhibitors increase tadalafil exposure. Enclomiphene interacts with estrogen-modulating therapies. Full medication disclosure to your provider is required before starting.

Is Gonadorelin / Enclomiphene / Oxytocin / Tadalafil / PT-141 Troche safe if I have a pre-existing medical condition?

Cardiovascular conditions require fitness-for-sexual-activity evaluation before starting. Hypertension must be controlled before introducing PT-141. Hepatic and renal impairment affect tadalafil metabolism and require provider dose evaluation. Regular hormone monitoring is recommended throughout treatment.

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Hours

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  • Licensed Provider

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  • HIPAA Compliant

  • LegitScript Certified

The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.