Natural T + Sperm Boost

Gonadorelin

Enclomiphene + DHEA

Pregnenolone

A four-active sublingual troche restoring natural testosterone production and replenishing the adrenal steroid precursors that decline alongside it

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Overview

Gonadorelin 500 mcg / Enclomiphene 25 mg / DHEA 25 mg / Pregnenolone 50 mg

Testosterone deficiency in aging men rarely exists in isolation. DHEA-S, pregnenolone, and the upstream hormonal signals that drive steroidogenesis all decline together. This formula addresses the full picture: gonadorelin and enclomiphene restore HPG axis output through two complementary mechanisms, while DHEA and pregnenolone replenish the adrenal androgen precursor pool that feeds peripheral testosterone and neurosteroid synthesis.

Mechanism of Action

Gonadorelin provides pulsatile GnRH stimulation to drive pituitary LH and FSH release. Enclomiphene blocks hypothalamic and pituitary estrogen receptors to amplify gonadorelin's signal by removing estrogenic negative feedback. DHEA supplements adrenal androgen precursor output, serving as a direct peripheral substrate for testosterone and estrone synthesis. Pregnenolone replenishes the master steroid precursor that feeds the entire steroidogenic cascade including DHEA, progesterone, and downstream sex hormone pathways.

Oral

Dissolve one troche under your tongue before bed

Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.

Benefits

Energy

DHEA and pregnenolone replenish the adrenal precursors responsible for daytime energy and stress resilience that drop significantly after age 30.

Lean Muscle

Dual HPG axis stimulation restores testosterone-driven protein synthesis and body composition support through natural mechanisms.

Mood and Stress

Pregnenolone acts as a neurosteroid at GABA and NMDA receptors, supporting mood stability, cognitive clarity, and stress regulation.

Sexual Health

Comprehensive hormonal precursor support alongside HPG axis stimulation restores the hormonal foundation for libido and sexual function.

Fertility

Gonadorelin and enclomiphene together preserve FSH-driven spermatogenesis, making this protocol appropriate for men who want hormonal optimization without compromising fertility.

Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.

Simple. Medical.

Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.

Provider evaluation

A licensed medical provider reviews your intake to determine the safest, personalized treatment.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, & biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.

All eligibility is reviewed by a licensed medical professional

FAQs

What is Gonadorelin / Enclomiphene / DHEA / Pregnenolone Troche?

A compounded sublingual troche combining two HPG axis stimulants with two adrenal steroid precursors to restore natural testosterone production and replenish the upstream hormonal substrate that supports it. Doses are listed on your order form.

Who should use Gonadorelin / Enclomiphene / DHEA / Pregnenolone Troche?

Men with low testosterone accompanied by low DHEA-S or pregnenolone levels who want to address the full hormonal decline picture rather than testosterone alone. Provider evaluation and baseline labs are required.

Does Gonadorelin / Enclomiphene / DHEA / Pregnenolone Troche require a prescription?

Yes. Gonadorelin and enclomiphene are prescription medications. A valid prescription from a licensed provider is required, along with hormone panel monitoring throughout treatment.

What are the possible side effects?

Gonadorelin: flushing or mild headache. Enclomiphene: elevated estradiol and mood variability. DHEA and pregnenolone: acne, oily skin, and androgenic or estrogenic effects at higher circulating levels. Hormone monitoring manages these throughout treatment.

Who Should Not Use Gonadorelin / Enclomiphene / DHEA / Pregnenolone Troche?

Not for men with primary hypogonadism, hormone-sensitive malignancies, or hepatic impairment without specialist evaluation. Not appropriate for patients on concurrent exogenous testosterone or anabolic steroids, as these suppress the HPG axis response to gonadorelin and enclomiphene.

Are there any drug interactions?

DHEA and pregnenolone may affect estradiol levels in patients on aromatase inhibitors. Enclomiphene interacts with other estrogenic or anti-estrogenic medications. Disclose all medications and supplements to your provider before starting.

Is Gonadorelin / Enclomiphene / DHEA / Pregnenolone Troche safe if I have a pre-existing medical condition?

Patients with adrenal disorders, hepatic impairment, or hormone-sensitive conditions require provider evaluation. Baseline and follow-up labs including testosterone, DHEA-S, estradiol, LH, and FSH are recommended throughout treatment.

Contact Us

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Hours

Monday–Saturday, 10am–8pm ET

Text or Call

Hours

Monday–Saturday, 10am–8pm ET

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No clinic visits required.

  • Licensed Provider

  • Licensed Pharmacy

  • HIPAA Compliant

  • LegitScript Certified

The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.