Fat Burner + energy
AMPK O-304
AMPK activator that mimics the metabolic effects of exercise and fasting — burning fat, improving blood sugar, and boosting cellular energy.
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Overview
Pharmacology
O-304 is an orally bioavailable, peripherally restricted small-molecule pan-AMPK activator. It acts selectively on metabolic tissues - skeletal muscle, liver, adipose tissue, and cardiovascular tissue - without significant central nervous system activity. This peripheral restriction means O-304 delivers broad metabolic benefits without stimulant effects, appetite suppression, or mood changes associated with centrally acting compounds.
Mechanism of Action
O-304 binds to the ADaM site on the AMPK enzyme - the same energy-sensing kinase activated by exercise and fasting - triggering sustained activation across metabolic tissues. Once activated, AMPK simultaneously switches on fat oxidation, glucose uptake, and mitochondrial biogenesis while switching off fat storage, hepatic glucose output, and lipid synthesis. It also activates autophagy for cellular repair and reduces PCSK9 to lower LDL cholesterol. The net effect is a coordinated metabolic shift that mimics the cellular response to exercise and caloric restriction.
Oral
Taken by mouth once daily. No injection required.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Fat Burning Without Stimulants
Fatty acid oxidation, no CNS activity
Blood Sugar & Insulin Control
Glucose uptake, insulin sensitivity, independent of GLP-1
Mitochondrial Power
Biogenesis, energy, endurance
Liver Health
NAFLD, hepatic steatosis, fibrosis protection
Cellular Repair & Longevity
Autophagy, oxidative stress reduction
Heart & Cholesterol
PCSK9 reduction, LDL lowering, cardiovascular protection
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
Simple. Medical.
Personalized.
Medical intake
Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.
Provider evaluation
A licensed medical provider reviews your intake to determine the safest, personalized treatment.
Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.
All eligibility is reviewed by a licensed medical professional
FAQs
What is AMPK O-304?
AMPK O-304 is a prescription therapy used for metabolic support.
Who should use AMPK O-304?
Patients seeking support for metabolic support may qualify after evaluation by a licensed provider.
Does AMPK O-304 require a prescription?
Yes. O-304 is a compounded prescription medication that requires a valid prescription from a licensed provider. It is not available over the counter. Your provider will review your medical history and labs before prescribing to ensure it is appropriate for you.
What are the possible side effects?
The most commonly reported side effects are mild and transient, including gastrointestinal discomfort, nausea, and loose stools — particularly during the first few weeks as your body adjusts. Some patients may experience mild fatigue or dizziness, especially if blood pressure or blood sugar drops below their baseline. Serious side effects are rare. Contact your provider if you experience signs of hypoglycemia, significant lightheadedness, or any unusual symptoms after starting.
Who should not use AMPK O-304?
Patients with severe liver disease, severe kidney disease, or uncontrolled hypotension should not use O-304. It is also not recommended for pregnant or breastfeeding women, patients under 18, or anyone with a known hypersensitivity to any component of the formulation. Patients on insulin or sulfonylureas require close provider monitoring before starting due to additive blood sugar-lowering effects.
Are there any drug interactions?
The most clinically relevant drug interactions involve medications that also lower blood sugar — including insulin, metformin, and sulfonylureas. Combining these with O-304 may produce an additive effect and increase the risk of hypoglycemia, requiring dose adjustments. Patients on antihypertensive medications should also be monitored, as O-304 can further lower blood pressure. Inform your provider of all current medications before starting.
Is AMPK O-304 safe if I have a pre-existing medical condition?
O-304 should be used with caution or avoided in patients with severe liver disease, severe kidney disease, hypotension, or active hypoglycemia. It is also not recommended for insulin-dependent diabetics on sulfonylureas without close monitoring, as its blood sugar-lowering effects can increase hypoglycemia risk when combined with those medications.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.