Semax N-Acetyl

Semax N-Acetyl is a synthetic heptapeptide analogue of ACTH (4-10) with neuroprotective and nootropic properties. It rapidly elevates BDNF levels in the hippocampus and engages the melanocortin system — supporting cognitive function, mood, nociception, and neurological resilience.

🚫Shipping Restrictions: South Lake Pharmacy is not licensed to ship directly to the following states: Alabama, California, DC, Louisiana, Massachusetts, Michigan, Mississippi, Montana, Texas, Washington, and West Virginia.

Overview

Semax is a heptapeptide and synthetic analogue of a fragment of adrenocorticotropic hormone — specifically ACTH (4-10). It is predominantly classified as a nootropic with neurogenic and neurorestorative properties. Semax rapidly elevates levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus. Over the past two decades, research into the melanocortin system has revealed its significant role in memory, reward, mood, nociception, and neuroprotection — making Semax a compelling subject for therapeutic development in cognitive and neurological health.

Feel

Brain fog, reduced mental clarity, low motivation, or cognitive fatigue that limits daily performance

Want to support

Neurological resilience, BDNF elevation, mood regulation, and enhanced cognitive function

Experience

Stress-related cognitive decline, mood instability, or difficulty with memory and executive function

Care about

A non-systemic, intranasal delivery format that targets the CNS with precision and minimal invasiveness

Important: Compounded products are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality. This product requires a prescription from a licensed health professional. Information presented here is for educational purposes only. Must be 18 or older to order.

Mechanism & Properties

BDNF Upregulation

Neurogenic / Neurorestorative

Semax rapidly elevates levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus. BDNF plays a critical role in neuronal survival, synaptic plasticity, and the formation of long-term memory — pathways central to learning and cognitive resilience.

ACTH Analogue Activity

Heptapeptide — ACTH (4-10)

As a synthetic analogue of the ACTH (4-10) fragment, Semax retains the neurotrophic and neuroprotective properties of adrenocorticotropic hormone without its endocrine effects. The exact full mechanism of action remains under investigation, with ongoing research continuing to define its CNS activity profile.

Intranasal Delivery

Once Daily — One Spray Per Nostril

Administered as a nasal spray, Semax bypasses the blood-brain barrier through olfactory and trigeminal nerve pathways, allowing direct CNS access. This non-invasive route offers targeted delivery to relevant brain structures with a straightforward once-daily protocol.

All eligibility is reviewed by a licensed medical professional.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

Dosage & Administration

Instill one spray in each nostril once daily. Prime the nasal spray before first use according to your pharmacy's instructions. Tilt your head slightly forward, insert the tip gently into one nostril, and depress the pump while breathing in lightly. Repeat for the other nostril. Do not exceed the prescribed dose. Your provider may adjust the protocol based on your individual response and therapeutic goals.

Precautions & Side Effects

Semax N-Acetyl is a compounded prescription medication and is not FDA-approved or evaluated by the FDA for safety, efficacy, or quality. It requires a valid prescription from a licensed healthcare provider. Must be 18 or older to order. Not available for shipping to Alabama, California, DC, Louisiana, Massachusetts, Michigan, Mississippi, Montana, Texas, Washington, or West Virginia. Consult your provider before use if you have any existing neurological, psychiatric, or endocrine conditions.

Storage

Store Semax N-Acetyl nasal spray in the refrigerator at 36°F–46°F (2°C–8°C) to maintain peptide stability. Keep the bottle tightly capped and away from light when not in use. Do not freeze. Keep out of reach of children. Use within the beyond-use date specified by your compounding pharmacy. If the solution appears discolored or contains particulate matter, do not use and contact your pharmacy.

The information and products provided on this website are for educational and wellness purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Individual results may vary, and products carry potential risks and side effects. Certain products may not be evaluated by the U.S. Food and Drug Administration (FDA) unless explicitly stated. Services are provided by licensed physicians and nurse practitioners in states where they are authorized to practice, including California, Florida, Nevada, and other participating states. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, and Telehealth Consent. You must be 18 years of age or older to use this service.