Semaglutide Troche

Semaglutide/B12/Pyridoxine is a compounded oral medication taken as one tablet under the tongue daily. It may help regulate blood sugar, reduce appetite, and lower inflammation by activating a key receptor in the body — leading to better glucose control and weight management. As a compounded preparation, it is not an FDA-approved drug product.

Overview

This troche combines three active ingredients into a single sublingual tablet. Semaglutide acts as a GLP-1 receptor agonist to support glucose regulation and appetite control. Methylcobalamin (B12) and Pyridoxine (B6) contribute to neurological function, energy metabolism, and homocysteine regulation.

Sublingual delivery allows the active compounds to absorb directly through the mucosa, bypassing first-pass hepatic metabolism. Available through a valid prescription from a licensed healthcare provider via telemedicine consultation.

Adults seeking blood sugar regulation through a daily oral option

Adults seeking blood sugar regulation through a daily oral option

Patients who want B12 and B6 support alongside GLP-1 therapy

A convenient sublingual alternative to injectable semaglutide

Prescription Only · Strive Pharmacy

Formulation & Ingredient Breakdown

Semaglutide

GLP-1 Receptor Agonist

Activates GLP-1 receptors to stimulate glucose-dependent insulin secretion, suppress glucagon, and slow gastric emptying — reducing appetite and supporting weight management.

Methylcobalamin (B12)

Active Coenzyme Form

The bioactive form of vitamin B12. Supports neurological function, DNA synthesis, red blood cell formation, and energy metabolism. May help offset potential B12 depletion associated with GLP-1 therapy.

Pyridoxine (B6)

Essential B-Vitamin

Involved in over 100 enzymatic reactions including amino acid metabolism and neurotransmitter synthesis. Works synergistically with B12 to support homocysteine metabolism and reduce inflammation.

Sublingual Delivery

Administered under the tongue once daily. Sublingual absorption bypasses the gastrointestinal tract and first-pass liver metabolism, allowing compounds to enter systemic circulation more directly than standard oral tablets.

Compounded Preparation

This product is compounded by Strive Pharmacy and is not an FDA-approved drug product. It is prepared specifically for patients with a valid prescription from a licensed provider following a telemedicine consultation.

All eligibility is reviewed by a licensed medical professional.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

Dosage & Administration

Directions: Take one tablet under the tongue daily. Allow the troche to dissolve completely — do not chew or swallow whole. Do not eat or drink for 15 minutes after administration.

Form: Sublingual troche  ·  Frequency: Once daily  ·  Route: Sublingual

Dosage is determined by your prescribing provider. Do not adjust your dose without medical guidance.

Precautions

Inform your provider of all current medications and medical conditions before starting. Do not use alongside injectable semaglutide or other GLP-1 receptor agonists. Not recommended during pregnancy or breastfeeding.

Common side effects associated with GLP-1 therapy include nausea, vomiting, diarrhea, and abdominal discomfort — particularly when beginning treatment. Contact your provider if symptoms are severe or persistent.

This is a compounded preparation and is not FDA-approved. Individual results may vary.

Storage

Store as directed by Strive Pharmacy — typically refrigerated at 36–46°F (2–8°C), away from light and moisture. Keep out of reach of children.

Do not use if the troche appears discolored or has an unusual odor. Follow all storage and disposal instructions provided with your order.

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