Semaglutide ODT

Semaglutide / Methylcobalamin ODT is a compounded oral disintegrating tablet that combines a GLP-1 receptor agonist with vitamin B12. It dissolves rapidly on the tongue for needle-free delivery, supporting weight management, blood sugar regulation, and metabolic health.

Overview

Important: Semaglutide / Methylcobalamin ODT is a compounded medication available only through a 503A compounding pharmacy via patient-specific prescription. Compounded medications are not FDA-approved and have not been reviewed for safety or efficacy. This medication has not undergone clinical trials.

This compounded formulation combines semaglutide — a GLP-1 receptor agonist — with methylcobalamin, an active form of vitamin B12. The orally disintegrating tablet format dissolves within seconds to minutes when placed on the tongue, releasing both active ingredients for absorption through the oral mucosa and gastrointestinal tract. It is prepared specifically for individual patients when a commercially available medication is not appropriate for their needs, and is particularly valuable for patients who have experienced difficulties with standard formulations or require specific dose adjustments.

Feel

Persistent hunger, uncontrolled appetite, or difficulty achieving weight loss through diet and lifestyle alone

Want to support

Healthy weight management, blood sugar regulation, and improved metabolic function without injections

Experience

Blood sugar fluctuations, insulin resistance, or low energy related to vitamin B12 insufficiency

Care about

A personalized, needle-free delivery format that's discreet, convenient, and tailored to your biology

Directions: Place tablet on tongue and allow to dissolve completely — no water needed.

Do not chew or swallow whole. Take as directed by your prescribing provider.

Formulation & Ingredients

Semaglutide

GLP-1 Receptor Agonist — Primary Active

Semaglutide mimics glucagon-like peptide-1 to slow gastric emptying, reduce appetite signaling in the brain, and improve postprandial glucose response. It is well-established for its role in weight management and blood sugar control, now delivered in a convenient tablet format.

Methylcobalamin

Active Vitamin B12 — Neurological Support

Methylcobalamin is the bioactive, coenzyme form of vitamin B12 that the body can use directly without conversion. It supports neurological function, red blood cell formation, and energy metabolism — and may help offset B12 depletion that can occur with GLP-1 receptor agonist therapy.

ODT Delivery System

Dissolves in Seconds — No Water Needed

The orally disintegrating tablet employs specialized excipients for rapid dissolution on contact with saliva. Both active ingredients are released for absorption through the oral mucosa and GI tract, offering a needle-free alternative for patients who prefer or require non-injectable administration.

Compounded Formulation

503A Pharmacy — Patient-Specific

Prepared by a 503A compounding pharmacy pursuant to an individual patient prescription. This personalized approach allows for specific dose adjustments not available in commercial products, following a physician's determination that a commercially available medication is not appropriate for the patient.

All eligibility is reviewed by a licensed medical professional.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

Dosage & Administration

Place the Semaglutide / Methylcobalamin ODT tablet directly on your tongue and allow it to dissolve completely — do not chew, crush, or swallow the tablet whole. The tablet typically dissolves within seconds to minutes upon contact with saliva. Both active ingredients are then released for absorption through the oral mucosa and gastrointestinal tract. Take exactly as directed by your prescribing provider. Your dose may be gradually adjusted over time to minimize gastrointestinal side effects and optimize therapeutic response.

Precautions & Side Effects

This is a prescription-only compounded medication dispensed through a 503A compounding pharmacy. It is not FDA-approved and has not undergone clinical trials. Contraindicated in patients with medullary thyroid carcinoma history, MEN2, known hypersensitivity, severe GI disease, Leber's disease, or pregnancy. Women of childbearing potential should use effective contraception and discontinue at least two months before planned pregnancy due to semaglutide's long elimination half-life. Not available for shipping to California.

Storage

Store Semaglutide / Methylcobalamin ODT tablets in a cool, dry place away from direct light, heat, and moisture. Keep at controlled room temperature unless otherwise directed by your compounding pharmacy. Do not store in humid environments such as bathrooms. Keep packaging tightly closed between uses. Keep out of reach of children and use within the beyond-use date specified on your prescription label.

The information and products provided on this website are for educational and wellness purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Individual results may vary, and products carry potential risks and side effects. Certain products may not be evaluated by the U.S. Food and Drug Administration (FDA) unless explicitly stated. Services are provided by licensed physicians and nurse practitioners in states where they are authorized to practice, including California, Florida, Nevada, and other participating states. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, and Telehealth Consent. You must be 18 years of age or older to use this service.