Skincare + Pigmentation + Anti-Aging

Rejuvenate

A three-active prescription formula that corrects hyperpigmentation, melasma, and uneven skin tone from three independent points in the pigmentation cascade.

  • No Insurance Required

  • Ships From USA Pharmacy

  • Free Medical Consultation

  • No Subscription Required

  • Licensed Provider

  • Licensed Pharmacy

  • HIPAA Compliant

  • LegitScript Certified

Overview

Tranexamic Acid / Tretinoin / Niacinamide

Three actives targeting hyperpigmentation at three independent points: tranexamic acid blocks UV-induced melanin production upstream, tretinoin normalizes melanocyte activity and clears accumulated pigment through cell turnover, and niacinamide blocks melanosome transfer downstream while buffering retinoid irritation.

Mechanism of Action

Tranexamic acid interrupts keratinocyte-to-melanocyte signaling to block melanin synthesis at its source. Tretinoin normalizes melanocyte activity, accelerates surface cell turnover, and stimulates collagen. Niacinamide inhibits melanosome transfer, reinforces the skin barrier, and suppresses the inflammation that drives post-inflammatory hyperpigmentation.

Topical Application

Applied to face nightly as directed by your provider. Sun protection required during daytime.

Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded products are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.

Benefits

Skin

Triple-mechanism pigmentation correction targeting melanin synthesis, melanocyte dysregulation, and melanosome transfer simultaneously for melasma, sunspots, and post-inflammatory hyperpigmentation.

Reducing Inflammation

Dual anti-inflammatory activity from tranexamic acid and niacinamide reduces the inflammatory signaling that drives and perpetuates post-inflammatory hyperpigmentation.

Healing

Tretinoin drives collagen synthesis and skin renewal alongside pigmentation correction, providing anti-aging structural benefits in every application.

Confidence

Addresses the three most common types of hyperpigmentation in one formula, for patients whose uneven tone has multiple overlapping causes.

Prevention

Tranexamic acid blocks UV-induced re-pigmentation upstream, making it particularly effective in patients whose pigmentation is maintained by ongoing sun exposure.

These statements have not been evaluated by the U.S. Food and Drug Administration and should not be interpreted as medical advice or a guarantee of treatment outcomes.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

All eligibility is reviewed by a licensed medical professional.

What Patients Are Experiencing

"Melasma has been the most stubborn skin concern I have ever tried to treat. Rejuvenate is the first formula that has actually moved it."

— Priya K.*

"Post-acne marks that had been there for two years faded significantly in 10 weeks. The three-mechanism approach works."

— Tanya B.*

"Even skin tone for the first time in years. My provider added strict SPF compliance and the combination has been transformative."

— Lisa W.*

*Individual experiences may vary. Not all patients will have the same outcomes.

FAQs

Does Rejuvenate require a prescription?

Yes. Rejuvenate contains tretinoin, a prescription-only teratogenic retinoid. A valid prescription from a licensed provider is required.

What are the possible side effects?

Common side effects include nausea, vomiting, diarrhea, constipation, abdominal discomfort, reduced appetite, injection site reactions, fatigue, and headache. These are most frequently reported during dose escalation and typically diminish over time.

Who Should Not use Rejuvenate?

Contraindicated in pregnancy and breastfeeding. Not for patients with known retinoid hypersensitivity, documented allergy to tranexamic acid or niacinamide, or active inflamed or eczematous skin. Patients on oral tranexamic acid for systemic indications should disclose this to their provider.

Are there any drug interactions?

enzoyl peroxide inactivates tretinoin on contact. AHAs and BHAs increase barrier disruption risk when combined with tretinoin, particularly during the adjustment period. Hormonal contraceptives and menopausal HRT are major melasma drivers and should be disclosed, as they require ongoing sun protection and maintenance therapy to manage alongside this formula.

Is Rejuvenate safe if I have a pre-existing medical condition?

Patients with active eczema or compromised skin barrier should stabilize their skin before starting tretinoin therapy. Patients with a history of severe post-inflammatory hyperpigmentation require gradual introduction. Reliable contraception is required for women of reproductive age throughout treatment.

Start Your Journey

Ready to Finally Even

Your Skin Tone?

Physician-prescribed Rejuvenate compounded and delivered to your door. No clinic visits required

  • Licensed Provider

  • Licensed Pharmacy

  • HIPAA Compliant

  • LegitScript Certified

The information and products provided on this website are for educational and wellness purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Individual results may vary, and products carry potential risks and side effects. Certain products may not be evaluated by the U.S. Food and Drug Administration (FDA) unless explicitly stated. Services are provided by licensed physicians and nurse practitioners in states where they are authorized to practice, including California, Florida, Nevada, and other participating states. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, and Telehealth Consent. You must be 18 years of age or older to use this service.