Collagen + Peptide
GHK-Cu
Rebuilds collagen, accelerates wound healing, and reverses visible signs of skin aging.
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Overview
Pharmacology
Naturally occurring human tripeptide that binds copper ions and declines with age, correlating with loss of skin firmness, impaired healing, and increased oxidative stress.
Mechanism of Action
Activates fibroblasts to upregulate collagen, elastin, and glycosaminoglycan synthesis while modulating copper-mediated redox activity to reduce inflammation and oxidative damage at the cellular level.
Topical
Apply cream to face once daily, preferably in the evening.
Information presented here is for educational purposes only and not intended to replace or substitute guidance from a healthcare provider. Compounded medications are not FDA-approved nor evaluated by the FDA for safety, efficacy, or quality.
Benefits
Skin Rejuvenation
GHK-Cu stimulates collagen and glycosaminoglycan synthesis, supporting reduction of fine lines, improved skin firmness, elasticity, and correction of photodamage, mottled pigmentation, and sunspots.
Wound and Barrier Healing
Accelerates healing in chronic or slow-healing wounds, post-procedural skin recovery, and repair of the skin's protective barrier proteins. Fibroblast stimulation and angiogenesis both contribute to the healing response.
Structural Protein Synthesis
Upregulates collagen synthesis along with decorin, a proteoglycan that regulates collagen fibril diameter and organization. Proper decorin activity is the structural basis of smooth, firm, and resilient skin.
Hair Follicle Support
GHK-Cu supports hair follicle health and follicular regeneration, particularly in the context of age-related thinning. Topical application to the scalp delivers the peptide signal directly to the follicular environment.
Antioxidant and Anti-Inflammatory
As a copper-binding peptide, GHK-Cu modulates the redox activity of copper ions and reduces chronic low-grade inflammation, addressing the oxidative stress that drives much of the visible damage associated with skin aging.
Individual results may vary. Benefits described are based on clinical and pharmacological evidence and do not constitute a guarantee of treatment outcomes. All treatment requires evaluation and approval by a licensed provider.
Simple. Medical. Personalized.
Medical intake
Answer a few online questions about your health history, lifestyle, & goals. No clinic visits required.
Provider evaluation
A licensed medical provider reviews your intake to determine the safest, personalized treatment.
Personalized plan
Custom treatment plan built around your unique health needs, goals, medical history, & biology.
Ongoing support
Stay connected with your care team for follow-ups, adjustments, & expert answers 100% online.
What Patients Are Experiencing
"The texture of my skin changed noticeably within the first few weeks. Firmer, more even, and the fine lines around my eyes have visibly softened. Nothing over the counter has come close to this result."
— Michael R.*
"A post-procedure wound I was concerned about healed faster than my provider expected. The cream was easy to apply and absorbed quickly. The blue tint disappears in seconds just as described."
— Daniel S.*
"The online consultation was quick and the prescription arrived without any issues. My skin feels noticeably more resilient and the overall tone has evened out in a way I have not seen with anything else."
— James K.*
*Individual experiences may vary. Not all patients will have the same outcomes.
FAQs
What is GHK-CU Anhydrous Base?
GHK-CU Anhydrous Base is a prescription therapy used for skin rejuvenation support.
Who should use GHK-CU Anhydrous Base?
Patients seeking support for skin rejuvenation support may qualify after evaluation by a licensed provider.
Does GHK-Cu require a prescription?
Yes. GHK-Cu is a compounded prescription topical preparation requiring a valid prescription from a licensed healthcare provider. A telehealth consultation and medical intake are required before dispensing to confirm suitability and establish the appropriate use protocol.
What are the possible side effects?
GHK-Cu applied topically has an excellent established safety record. Mild skin sensitivity or temporary irritation may occur during initial use in patients with very reactive skin. The cream has a characteristic blue hue from the copper complex; this is normal, absorbs cleanly within seconds, and does not stain skin. If significant or persistent redness, rash, or swelling develops, discontinue and contact your provider.
Who should not use GHK-Cu?
Patients with known sensitivity or allergy to copper peptides or copper compounds should not use this product. Those with Wilson's disease or copper metabolism disorders should not use copper-containing topicals without specialist guidance. Patients with active eczema, rosacea flares, or significantly compromised facial skin should introduce GHK-Cu gradually. Safety during pregnancy and breastfeeding has not been established — consult your provider before use.
Are there any drug interactions?
Concurrent use of copper-chelating topicals or systemic copper-chelating agents (D-penicillamine, trientine) may reduce GHK-Cu's activity. Patients using high-concentration retinoids, AHAs/BHAs, or strong oxidizing agents should discuss application sequencing and layering protocol with their provider to minimize potential barrier disruption. Discuss your full current skincare regimen before starting.
Is GHK-Cu safe if I have a pre-existing medical condition?
Patients with Wilson's disease or copper metabolism disorders require specialist assessment before using copper-containing topicals. Those with a history of malignancy should discuss use with their provider given GHK-Cu's gene-modulating and angiogenic properties. Patients with active inflammatory skin conditions should delay initiating treatment until skin is stable. Your provider will review your complete history before prescribing.
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The information and clinical services described on this website are for educational and informational purposes only and are not intended to diagnose, treat, cure, or prevent any disease. All treatments require evaluation and approval by a licensed healthcare provider through a telemedicine consultation. Treatment approval is not guaranteed. Individual results may vary, and treatments may carry risks and side effects. Certain compounded medications, wellness treatments, or off-label uses may not be evaluated by the U.S. Food and Drug Administration (FDA) for safety, effectiveness, or quality unless explicitly stated. Testosterone Shots provides telehealth consultations, clinical review, care coordination, lab-related services, membership services, and ongoing treatment management. Testosterone Shots is not a pharmacy and does not manufacture, compound, dispense, sell, handle, warehouse, ship, or collect payment for prescription medication. Testosterone Shots collects payment only for consultations, clinical review, care coordination, lab-related services, membership services, and other non-pharmacy services. If treatment is approved, your prescription may be sent to a licensed pharmacy partner. The pharmacy contacts you directly to complete medication payment and shipping. Services are provided by licensed physicians, nurse practitioners, and/or other licensed healthcare providers in states where they are authorized to practice. This service is not intended for medical emergencies. If you are experiencing an emergency, call 911 or seek immediate medical care. We take reasonable measures to protect personal health information in accordance with applicable privacy laws, including HIPAA. By using this website or its services, you agree to our Terms of Service, Privacy Policy, Notice of Privacy Practices, Telehealth Consent, and Important Safety Information. You must be 18 years of age or older to use this service.