GHK-Cu (Anhydrous Base) is a compounded topical copper peptide cream formulated in a water-free vehicle to preserve full peptide potency. It is prescribed by a licensed provider for skin rejuvenation, collagen synthesis, wound healing, and anti-aging applications. It is not FDA-approved and is not available over the counter. A telehealth consultation is required before dispensing.

GHK-Cu has a well-established safety profile in topical use. Possible side effects include mild skin irritation, redness, or sensitivity, particularly in patients with reactive or compromised skin. The characteristic blue hue from the copper complex absorbs without staining within seconds of application. Discontinue use and contact your provider if a persistent reaction develops or if the product enters the eyes.

Patients with a known sensitivity or allergy to copper peptides or copper compounds should not use this product. Those with active eczema, rosacea flares, or post-procedure skin should introduce the cream gradually and consult their provider before use. Use during pregnancy or breastfeeding should be discussed with your provider, as with all compounded topical preparations.

GHK-Cu (Anhydrous Base) is generally compatible with most skincare actives. Patients using high-concentration retinoids, AHAs, BHAs, or strong oxidizing agents should discuss their layering protocol with their provider, as combining aggressive topical actives can compromise skin barrier integrity. No systemic drug interactions have been identified for topical use at standard doses.

Patients with copper metabolism disorders such as Wilson's disease should discuss use with their provider before applying any copper-containing topical. Those with highly sensitive or compromised skin conditions should introduce the product gradually. Your provider requires a full medical and skin history before prescribing to ensure this formulation is appropriate for your individual needs.