GHK

This prescription-only, multi-active anti-aging formula combines peptides, estrogen support, and retinoids to improve skin elasticity, smooth fine lines, promote collagen production, and restore a youthful, glowing complexion—all in a single nightly application.

Overview

GHK-Cu / Estriol / Niacinamide / Tretinoin is a prescription-only, multi-active topical formula engineered to address the principal biochemical drivers of cutaneous aging through four synergistic mechanisms in a single nightly application. Rather than targeting a single pathway, this formula works across all four simultaneously—allowing each ingredient to reinforce the others in a coordinated approach to skin regeneration.

The copper peptide GHK-Cu stimulates collagen synthesis and activates wound-healing pathways. Estriol provides gentle hormonal support to restore skin plumpness and hydration. Niacinamide calms inflammation and evens tone, while Tretinoin—the gold standard in topical retinoids—accelerates cellular turnover and drives meaningful structural renewal.

"The result is a clinically coherent multi-active formula suited to patients seeking meaningful structural and aesthetic improvement in aging, hormonally-impacted, or photodamaged skin—particularly women in perimenopause and postmenopause."

Active Ingredients

Estriol

The mildest of the three naturally occurring human estrogens, estriol is dermally active and uniquely well-suited for topical dermatological use. It supports hyaluronic acid synthesis, GAG production, prolongs collagen lifespan, and improves dermal thickness—restoring the estrogen-depleted skin architecture responsible for a plump, hydrated complexion.

GHK-Cu Acetate

GHK-Cu is a naturally occurring copper-binding tripeptide with potent regenerative properties. It activates over 4,000 human genes involved in tissue repair, collagen and elastin synthesis, antioxidant defense, and anti-inflammatory signaling—making it one of the most versatile actives available in topical formulation today.

Niacinamide

Niacinamide is a water-soluble form of vitamin B3 with a broad therapeutic profile in dermatology. It improves skin barrier function, reduces melanin transfer (brightening hyperpigmentation), diminishes pore appearance, and regulates sebum. Its anti-inflammatory properties complement and buffer the irritation potential of Tretinoin.

Tretinoin

Tretinoin is the most clinically validated topical retinoid available for reversing photoaging. By binding retinoic acid receptors it stimulates keratinocyte turnover, promotes collagen synthesis, and inhibits MMP enzymes responsible for collagen degradation—producing measurable reduction in fine lines and wrinkles over time.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

How do the four ingredients work together?

Each ingredient targets a distinct mechanism of aging, and their effects are synergistic. GHK-Cu rebuilds collagen and activates repair pathways; Estriol restores hormonal skin support and hydration; Tretinoin drives cellular turnover and structural renewal; and Niacinamide calms inflammation, brightens tone, and helps buffer the irritation that Tretinoin can cause. Together, they form a more complete anti-aging system than any single ingredient could provide.

Is this formula FDA-approved?

This is a compounded prescription product prepared by Strive Pharmacy. Compounded medications are not FDA-approved or evaluated by the FDA for safety, efficacy, or quality. They are legally prepared by licensed compounding pharmacies to meet individual patient needs as prescribed by a licensed healthcare provider. Each ingredient in this formula has a well-established safety profile in peer-reviewed literature.

Who is this formula best suited for?

This formula is particularly well-suited for women in perimenopause and postmenopause whose skin has been doubly affected by intrinsic aging and estrogen decline. It is also appropriate for adults experiencing photoaging, fine lines, uneven texture, dullness, or loss of elasticity. A provider will evaluate your intake to ensure it is the right fit for your skin and health profile.

What side effects should I be aware of?

Tretinoin is the ingredient most associated with initial adjustment effects, including dryness, flaking, redness, and increased sensitivity—especially during the first 4–8 weeks. Niacinamide is included in part to mitigate these effects. Estriol applied topically is considered low-risk, but systemic absorption is possible. Your provider will discuss any personal risk factors during your consultation. Always use broad-spectrum SPF during the day when using this formula.

When will I start seeing results?

Most patients notice improvements in skin texture, hydration, and radiance within 4–8 weeks. More significant structural changes—reduction in fine lines, improved firmness, and visible collagen remodeling—typically become apparent after 3–6 months of consistent nightly use. Results vary depending on baseline skin condition, age, and adherence to the regimen.

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