Enclomiphene

Enclomiphene is the active isomer of clomiphene — a selective estrogen receptor modulator that stimulates your body's own testosterone production through the HPG axis, while preserving fertility and avoiding the side effects associated with exogenous testosterone or traditional clomiphene.

Overview

Enclomiphene is a selective estrogen receptor modulator (SERM) and the active trans-isomer of clomiphene citrate. Traditional clomiphene contains two isomers: enclomiphene, which drives the desirable pharmacological effects, and zuclomiphene, which is largely responsible for its estrogenic side effects. By isolating enclomiphene, this formulation delivers the testosterone-boosting benefits of clomiphene with a significantly reduced side effect burden — making it one of the most compelling oral alternatives to testosterone replacement therapy for men who want to preserve fertility.

Feel

Low energy, reduced libido, mood changes, difficulty building muscle, or symptoms of hypogonadism

Want to support

Natural testosterone production, fertility preservation, improved body composition, and hormonal balance

Diagnosed with

Hypogonadism or low testosterone, particularly men who want to maintain sperm production and avoid testicular atrophy

Prefer

An oral tablet over weekly injections, with a mechanism that works with the body's own hormonal feedback loop

How Enclomiphene Works

Estrogen Receptor Blockade

Hypothalamic-Pituitary-Gonadal Axis

Enclomiphene blocks estrogen receptors in the hypothalamus, preventing estrogen from sending its normal negative feedback signal. The hypothalamus interprets this as low estrogen and responds by increasing GnRH secretion, which in turn drives the pituitary to release more LH and FSH — the two hormones that command testosterone production.

LH & Testosterone Surge

Leydig Cell Stimulation

The elevated LH signal activates Leydig cells in the testes to synthesize and secrete testosterone. This drives both systemic testosterone and intratesticular testosterone — the high local concentration required to maintain spermatogenesis. Unlike exogenous testosterone, this pathway preserves the testes' natural function and volume.

FSH & Spermatogenesis

Sertoli Cell Support · Fertility Preservation

Elevated FSH acts synergistically with LH, stimulating Sertoli cells to support sperm maturation, quality, and production. This dual LH/FSH elevation is what distinguishes enclomiphene from exogenous testosterone — which suppresses both LH and FSH, shutting down sperm production and causing testicular atrophy over time.

All eligibility is reviewed by a licensed medical professional.

Simple. Medical. Personalized.

Medical intake

Answer a few online questions about your health history, lifestyle, and goals — no clinic visits required.

Provider evaluation

A licensed medical professional reviews your intake and determines the safest, most effective option for you.

Personalized plan

Custom treatment plan built around your unique health needs, goals, medical history, and biology.

Ongoing support

Stay connected with your care team for follow-ups, adjustments, and expert answers — all online.

FAQs

Dosage & Administration

Take one tablet by mouth once daily. The standard dose range is 12.5–25 mg per day, with your provider determining the appropriate starting dose and any adjustments based on lab work and clinical response. Enclomiphene has a 10-hour half-life, so consistent once-daily dosing maintains stable serum levels. A typical treatment course runs 2–3 months, after which hormone levels are reassessed. Take with or without food at a consistent time each day.

Precautions & Side Effects

Enclomiphene is a compounded prescription medication. It is not FDA-approved or evaluated by the FDA for safety, efficacy, or quality. A valid prescription from a licensed healthcare provider is required. Must be 18 or older to order. Consult your provider before use if you have existing liver conditions, hormone-sensitive conditions, visual disorders, or a history of thromboembolic events. Report any visual changes to your provider immediately. Regular hormone panel monitoring (LH, FSH, testosterone, estradiol) is recommended during the treatment course.

Storage

Store Enclomiphene tablets at controlled room temperature, away from heat, direct light, and moisture. Keep in the original container with the lid tightly closed. Do not store in humid environments such as bathrooms. Keep out of reach of children. Use within the beyond-use date specified on your prescription label from Strive Pharmacy.

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