
5-in-1 prescription cream that eliminates acne-causing bacteria, clears pores, reduces inflammation, and restores skin texture.
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Yes. This formula contains tretinoin and clindamycin, both of which require a valid prescription from a licensed provider.
Expect dryness, peeling, redness, and a purging phase during weeks 1-4. Tretinoin increases sun sensitivity, requiring daily SPF. Prolonged clindamycin use can promote antibiotic resistance, which benzoyl peroxide is included to prevent.
Avoid during pregnancy due to tretinoin. Not recommended for patients with inflammatory bowel disease or a history of Clostridioides difficile, as clindamycin carries a rare risk of C. difficile-associated diarrhea.
Benzoyl peroxide deactivates tretinoin on contact. Apply them at separate times or use this pre-combined formula as directed. Clindamycin may interact with neuromuscular blocking agents. Disclose all medications to your provider.
Patients with inflammatory bowel disease, C. difficile history, or known retinoid sensitivity require provider evaluation before starting. Tretinoin is contraindicated in pregnancy.
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